Journal of Antibiotics 1996-01-01

A-72363 A-1, A-2, and C, novel heparanase inhibitors from Streptomyces nobilis SANK 60192, II. Biological activities.

Y Kawase, M Takahashi, T Takatsu, M Arai, M Nakajima, K Tanzawa

Index: J. Antibiot. 49(1) , 61-4, (1996)

Full Text: HTML

Abstract

Inhibitory activities of A-72363 A-1, A-2 and C, the diastereomers of a neuraminidase inhibitor siastatin B, against various glycosidases were tested in comparison to siastatin B. Despite these compounds differing only in their configuration, each compound showed strikingly different specificities towards the various glycosidases tested. A-72363 C inhibited bovine liver beta-glucuronidase and tumor cell heparanase with IC50 values of 1.6 microM and 12 microM, respectively.


Related Compounds

Related Articles:

Contributions of NanI sialidase to Caco-2 cell adherence by Clostridium perfringens type A and C strains causing human intestinal disease.

2014-11-01

[Infect. Immun. 82(11) , 4620-30, (2014)]

Syntheses and activities of N-substituted derivatives of siastatin B.

1992-10-01

[J. Antibiot. 45(10) , 1662-8, (1992)]

Synthesis of 3-episiastatin B analogues having anti-influenza virus activity.

1993-12-01

[J. Antibiot. 46(12) , 1883-9, (1993)]

Synthesis of the sialidase inhibitor siastatin B.

2007-05-01

[Org. Lett. 2 , 4037, (2000)]

A-72363 A-1, A-2 and C, novel heparanase inhibitors from Streptomyces nobilis SANK 60192. I. Taxonomy of producing organism, fermentation, isolation and structure elucidation.

1996-01-01

[J. Antibiot. 49(1) , 54-60, (1996)]

More Articles...