China Journal of Chinese Materia Medica 2005-09-01

[Study on chemical constituents from Incarvillea arguta and their accelerating PC-12 cell differentiation].

Zheng-wen Yu, Hai-yan Zhu, Xiao-sheng Yang, Qian-yun Sun, Xiao-jiang Hao

Index: Zhongguo Zhong Yao Za Zhi 30(17) , 1335-8, (2005)

Full Text: HTML

Abstract

To study chemical constituents of Incarvillea arguta and their accelerating PC-12 cell differentiation.The constituents were isolated and repeatedly purified on silica gel column chromatography, and were identified on the basis of physicochemical and spectroscopic analysis. The neurotrophic activity of different portion and all purified compounds from I. arguta was determined on the model of PC-12 cell.Five compounds were isolated from BuOH portion of alcohol extraction of I. arguta. Their structures were identified as plantarenaloside (I), 5-hydroxy-4', 6 7-trimethoxy-flavone (II), 4', 5-dihydroxy-6, 7-dimethoxyflavone (III), 4', 5-dihydroxy-7-methoxyflavone (IV), 5-dydroxy-4', 7-dimethoxyflavone (V).Compound I is isolated from the plant for the first time and it has neurotrophic activity for PC-12 cell. Compounds II approximately V are isolated from the genus Incarvillea for the first time.


Related Compounds

Related Articles:

[Studies on flavonoid constituents from herbs of Artemisia ordosica II].

2006-12-01

[Zhongguo Zhong Yao Za Zhi 31(23) , 1959-61, (2006)]

[Determination of flavonoids in buds of Herba Artemisiae Scopariae by HPLC].

2005-04-01

[Zhongguo Zhong Yao Za Zhi 30(8) , 591-4, (2005)]

Analysis of vervain flavonoids by HPLC/Diode array detector method. Its application to quality control.

1999-11-01

[J. Agric. Food Chem. 47(11) , 4579-82, (1999)]

Inhibition of [methyl-3H]diazepam binding to rat brain membranes in vitro by dinatin and skrofulein.

1994-09-01

[Zhongguo Yao Li Xue Bao 15(5) , 385-8, (1994)]

Reactive oxygen species-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to cirsimaritin-induced apoptosis in human gallbladder carcinoma GBC-SD cells.

2010-09-28

[Cancer Lett. 295(2) , 252-9, (2010)]

More Articles...