Brain toxicokinetics of prometryne in mice.

Domagoj Dikić, Lana Sajli, Vesna Benković, Anica Horvat Knezević, Gordana Brozović, Duje Lisicić, Ana Mojsović, Nada Orsolić

Index: Arh. Hig. Rada Toksikol. 61(1) , 19-27, (2010)

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Abstract

Prometryne is a methylthio-s-triazine herbicide. Significant trace amounts are found in the environment, mainly in water, soil, and food plants. The aim of this study was to establish brain and blood prometryne levels after single oral dose (1 g kg-1) in adult male and female mice. Prometryne was measured using the GC/MS assay at 1, 2, 4, 8, and 24 h after prometryne administration. Peak brain and blood prometryne values were observed 1 h after administration and they decreased in a time-dependent manner. Male mice had consistently higher brain and blood prometryne levels than female mice. The observed prometryne kinetics was similar to that reported for the structurally related herbicide atrazine.