Toxicology Letters 2014-07-03

In vitrometabolism of benzo[a]pyrene and dibenzo[def,p]chrysene in rodent and human hepatic microsomes

S.R. Crowell, S. Hanson-Drury, D.E. Williams, R.A. Corley

Index: Toxicol. Lett. 228(1) , 48-55, (2014)

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Abstract

• PAH clearance was highest in naïve female mice and lowest in female humans. • PAH clearance rates in male rat were more similar to female human than female mice. • Metabolism of B[a]P was generally more rapid than DBC, regardless of organism. • DBC metabolism kinetics were reduced in the pregnant mouse relative to naïve mice.

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