Dibenzo[a,l]pyrene

Names

[ CAS No. ]:
191-30-0

[ Name ]:
Dibenzo[a,l]pyrene

[Synonym ]:
1,2,3,4-Dibenzpyrene
1,2,9,10-Dibenzopyrene
Dibenzo[a,l]pyrene
Dibenzo[def,p]chrysene
1,2:3,4-Dibenzopyrene
Dibenz<al>pyrene
dibenzopyrene
dibenzo<def,p>crysene
4,5,6,7-Dibenzpyrene
Naphtho[1,2,3,4-pqr]tetraphene

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
552.3±17.0 °C at 760 mmHg

[ Melting Point ]:
162.4ºC

[ Molecular Formula ]:
C₂₄H₁₄

[ Molecular Weight ]:
302.368

[ Flash Point ]:
282.0±15.1 °C

[ Exact Mass ]:
302.109558

[ LogP ]:
7.63

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.913

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable, but may be heat sensitive - keep cool. Combustible. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HO6125000

CHEMICAL NAME :: Dibenzo(def,p)chrysene

CAS REGISTRY NUMBER :: 191-30-0

BEILSTEIN REFERENCE NO. :: 2054068

LAST UPDATED :: 199801

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C24-H14

MOLECULAR WEIGHT :: 302.38

WISWESSER LINE NOTATION :: L D66 K666 B6 2AB A&J

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 96761 ug/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 890 mg/kg/37W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 48 mg/kg/4W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 72 mg/kg/9W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Rodent - mouse Embryo

DOSE/DURATION :: 100 ug/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 18,1973,1997 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 32,343,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 32,343,1983 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW 85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: Pc,4,1972 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FRANCE;Carcinogen JAN 1993

Safety Information

[ Symbol ]:

GHS05, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H412

[ Precautionary Statements ]:
P273

[ Target Organs ]:
Blood, Central nervous system, Liver

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
40

[ Safety Phrases ]:
23-24/25-36/37-45-26-53-39-61

[ RIDADR ]:
UN 2811

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2902909090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2902909090

[ Summary ]:
2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

Articles

In vitrometabolism of benzo[a]pyrene and dibenzo[def,p]chrysene in rodent and human hepatic microsomes

Toxicol. Lett. 228(1) , 48-55, (2014)

• PAH clearance was highest in naïve female mice and lowest in female humans. • PAH clearance rates in male rat were more similar to female human than female mice. • Metabolism of B[a]P was generally ...

Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR.

Toxicol. Lett. 222(2) , 180-8, (2013)

Metabolic activation of polycyclic aromatic hydrocarbons (PAH) is mediated mainly by cytochrome P₄₅₀ monooxygenases (CYP) CYP1A1, 1A2 and 1B1. Several PAH are known to induce these CYP via aryl hydroc...

The rainbow trout liver cancer model: Response to environmental chemicals and studies on promotion and chemoprevention

Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 155(1) , 121-7, (2012)

Rainbow trout ( Oncorhynchus mykiss) are an outstanding model of liver cancer induction by environmental chemicals and development of strategies for chemoprevention. Trout have critical and unique adv...