An assay for mutagenic activity of 4CMB, 4HMB and BC, using the "microtitre" fluctuation test.

M S Pour, C Merrill, J M Parry

Index: Mutat. Res. 100(1-4) , 81-5, (1982)

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Abstract

4CMB, 4HMB and BC were assayed for mutagenic activity using the 'microtitre' bacterial fluctuation test without metabolic activation. 4CMB was positive in strains of Salmonella typhimurium detecting both base-substitution and frameshift mutation. BC was weakly positive only in the strain which detects base-substitution mutation. 4HMB was negative in both strains. 4CMB and 4HMB were equally toxic to the strains, whilst BC was comparatively less toxic.