Substituted coumarins as potent 5-lipoxygenase inhibitors.
Erich L Grimm, Christine Brideau, Nathalie Chauret, Chi-Chung Chan, Daniel Delorme, Yves Ducharme, Diane Ethier, Jean-Pierre Falgueyret, Richard W Friesen, Jocelyne Guay, Pierre Hamel, Denis Riendeau, Chantal Soucy-Breau, Philip Tagari, Yves Girard
Index: Bioorg. Med. Chem. Lett. 16(9) , 2528-31, (2006)
Full Text: HTML
Abstract
Leukotriene biosynthesis inhibitors have potential as therapeutic agents for asthma and inflammatory diseases. A novel series of substituted coumarin derivatives has been synthesized and the structure-activity relationship was evaluated with respect to their ability to inhibit the formation of leukotrienes via the human 5-lipoxygenase enzyme.
Related Compounds
Related Articles:
One-pot synthesis of 3-amino-4-aryl-and 3-amino-4-hetarylfurazans. Sheremetev AB.
[Russ. Chem. Bull. 54(4) , 1057-59, (2005)]