Journal of Pharmaceutical and Biomedical Analysis 1997-06-01

Selected applications of capillaries with dynamic or permanent anodal electroosmotic flow in chiral separations by capillary electrophoresis.

B Chankvetadz, G Schulte, G Blaschke

Index: J. Pharm. Biomed. Anal. 15(9-10) , 1577-84, (1997)

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Abstract

The techniques for a dynamic and permanent reversal of the electroosmotic flow (EOF) were used for the reversal of the enantiomer migration order (EMO) of neutral and cationic analytes in chiral capillary electrophoresis (CE). Native beta-Cd and an anionic CD derivative, CM-beta-CD were used in both, bare silica- and positively coated capillaries. Advantages and disadvantages of a dynamic and permanent modification of the capillary inner surface are briefly discussed.