Hoppe-Seyler´s Zeitschrift für physiologische Chemie
1976-11-01
[1-Adamanty fluoroformate, a useful reagent in peptide chemistry (author's transl)].
L Moroder, L Wackerle, E Wünsch
Index: Hoppe. Seylers. Z. Physiol. Chem. 357 , 1647, (1976)
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Abstract
1-Adamantyl fluoroformate was prepared from 1-adamantol and fluorophosgene. The cristalline and stable fluoroformate was allowed to react with amino acids to give the corresponding 1-adamantyloxycarbonyl derivatives in consistently high yields. Additonally this new reagent proved to be ideally reactive for acylation of the imidazol function of histidine and histidyl-peptides.
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