Organic Letters 2009-03-19

A new and facile synthesis of quinazoline-2,4(1H,3H)-diones.

Jiarong Li, Xian Chen, Daxin Shi, Shuling Ma, Qing Li, Qi Zhang, Jianhong Tang

Index: Org. Lett. 11(6) , 1193-6, (2009)

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Abstract

A new and facile preparation of quinazoline-2,4(1H,3H)-diones was first reported which was the condensation of aromatic o-aminonitriles with DMF or N,N-diethylformamide in the presence of ZnCl(2) (0.5-10 mol %) at 190-200 degrees C in the sealed reactor.

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