Double-blind plethysmographic study of venous effects of heptaminol adenosine phosphate in patients with primary varicose veins.

C Schmidt, R Gavoille, P Perez, J Schmitt

Index: Eur. J. Clin. Pharmacol. 37(1) , 37-40, (1989)

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Abstract

Changes in venous haemodynamics were studied after administration of a single dose of 3 g Heptaminol Adenosine Phosphate (HAP) to 30 subjects with primary varicose veins. Strain gauge plethysmography was used to observe changes in venous volume and in maximal venous outflow, 1, 2, 3 and 4 h after dosing. A significantly greater reduction in these parameters was found after treatment with HAP compared to placebo, indicating an improvement in lower limb venous circulation.