THPN

Names

[ Name ]:
THPN

[Synonym ]:
1-(3,4,5)-Trihydroxyphenyl)nonan-1-one
1-(2,4,6-Trihydroxyphenyl)-1-nonanone
1-Nonanone,1-(2,4,6-trihydroxyphenyl)
1,2,3-Benzenetriol,4-(octylcarbonyl)
T94

Biological Activity

[Description]:

THPN is a potent Nur77 agonist. THPN specifically binds the LBD of Nur77 (TR3) but not that of retinoic acid receptor α and PPARγ with a Kd of 270 nM. THPN leads to Nur77 translocation to the mitochondria to induce autophagic cell death in melanoma[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Wei-jia Wang, et al. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat Chem Biol. 2014 Feb;10(2):133-40.

[2]. Li Li, et al. Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat Chem Biol. 2015 May;11(5):339-46.

Chemical & Physical Properties

[ Density]:
1.148g/cm3

[ Boiling Point ]:
483.5ºC at 760mmHg

[ Molecular Formula ]:
C₁₅H₂₂O₄

[ Molecular Weight ]:
266.33300

[ Flash Point ]:
260.3ºC

[ Exact Mass ]:
266.15200

[ PSA ]:
77.76000

[ LogP ]:
3.73670

[ Vapour Pressure ]:
5.69E-10mmHg at 25°C

[ Index of Refraction ]:
1.554

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

Articles

Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Li L et al

Nat. Chem. Biol. 11(5) , 339-46, (2015)