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Pimecrolimus hydrate

Names

[ CAS No. ]:
1000802-56-1

[ Name ]:
Pimecrolimus hydrate

Biological Activity

[Description]:

Pimecrolimus hydrate (SDZ-ASM 981 hydrate) is a potent, nonsteroid and orally active calcineurin inhibitor. Pimecrolimus hydrate shows anti-inflammatory activity. Pimecrolimus hydrate has the potential for the research of atopic dermatitis and oral erosive lichen planus[1][2][3].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Research Areas >> Inflammation/Immunology

[In Vitro]

Pimecrolimus hydrate (100 nM) targets T-cells and mast cells and inhibits the production and release of cytokines and other inflammatory mediators, as well as the expression of signals essential for the activation of inflammatory T-lymphocytes[1].

[In Vivo]

Pimecrolimus hydrate (10, 30 mg/kg; p.o.; daily for 4 weeks) increases in absolute numbers of T lymphocytes in KLH-immunised rats compared with non-immunised animals[2].

[References]

[1]. Grassberger M, et al. Pimecrolimus -- an anti-inflammatory drug targeting the skin. Exp Dermatol. 2004 Dec;13(12):721-30.

[2]. Roman D, et al. Determination of the effect of calcineurin inhibitors on the rat's immune system after KLH immunisation. Toxicol Lett. 2004 Apr 1;149(1-3):133-40.

[3]. Passeron T, et al. Treatment of oral erosive lichen planus with 1% pimecrolimus cream: a double-blind, randomized, prospective trial with measurement of pimecrolimus levels in the blood. Arch Dermatol. 2007 Apr;143(4):472-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C43H70ClNO12

Related Compounds