α-Cyclodextrin

Names

[ Name ]:
α-Cyclodextrin

[Synonym ]:
Ringdex A
(5R,10R,15R,20R,25R,30R,31R,32R,33R,34R,35R,36R,37R,38R,39R,40R,41R,42R)-5,10,15,20,25,30-hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxaheptacyclo[26.2.2.23,6.28,11.213,16.218,21.223,26]dotetracontane-31,32,33,34,35,36,37,38,39,40,41,42-dodecol
(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31R,32R,33R,34R,35R,36R,37R,38R,39R,40R,41R,42R)-5,10,15,20,25,30-Hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxaheptacyclo[26.2.2.2.2.2.2.2]dotetracontane-31,32,33,34,35,36,37,38,39,40,41,42-dodecol
α-CD,Cyclohexaamylose,cyclomaltohexaose
MFCD00078207
Cyclohexapentylose
(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31R,32R,33R,34R,35R,36R,37R,38R,39R,40R,41R,42R)-5,10,15,20,25,30-Hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxahe ;ptacyclo[26.2.2.2.2.2.2.2]dotetracontane-31,32,33,34,35,36,37,38,39,40,41,42-dodecol
α-Cyclodextrin
a-Schardinger Dextrin
CYCLOMALTOHEXOSE
cyclomaltodextrin
a-Cycloamylose
alpha-cyclodextrin
Alfadex
Schardinger α-Dextrin
CYCLOHEXAAMYLOSE
cyclomaltohexaose
alpha-Cycloamylose
(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31R,32R,33R,34R,35R,36R,37R,38R,39R,40R,41R,42R)-5,10,15,20,25,30-Hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxaheptacyclo[26.2.2.2.2.2.2.2]dotetracontan-31,32,33,34,35,36,37,38,39,40,41,42-dodecol
Celdex A 100
(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31R,32R,33R,34R,35R,36R,37R,38R,39R,40R,41R,42R)-5,10,15,20,25,30-Hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxaheptacyclo[26.2.2.2.2.2.2.2]dotetracontane-31,32,33,34,35,36,37,38,39,40,41,42-dodecol (non-preferred name)
α-Schardinger dextrin
α-Cycloamylose
a-Dextrin
Dexy Pearl a-100
α-Dextrin
a-Cyclodextrin.
EINECS 233-007-4
a-Cyclodextrin

Biological Activity

[Description]:

α-Cyclodextrin is a multifunctional, soluble dietary fiber marketed for use as a fiber ingredient.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Natural Products >> Others

Research Areas >> Others

[References]

[1]. Comerford KB, et al. The beneficial effects of α-cyclodextrin on blood lipids and weight loss in healthy humans. Obesity (Silver Spring). 2011 Jun;19(6):1200-4.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
1410.8±60.0 °C at 760 mmHg

[ Melting Point ]:
278ºC

[ Molecular Formula ]:
C₃₆H₆₀O₃₀

[ Molecular Weight ]:
972.844

[ Flash Point ]:
807.1±32.9 °C

[ Exact Mass ]:
972.316956

[ PSA ]:
474.90000

[ LogP ]:
-6.55

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.591

[ Storage condition ]:
Store at RT.

[ Water Solubility ]:
H2O: 50 mg/mL

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GU2292000

CHEMICAL NAME :: alpha-Cyclodextrin

CAS REGISTRY NUMBER :: 10016-20-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C36-H60-O30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 26,287,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 788 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925- Volume(issue)/page/year: 83,367,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4214 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2440 (estimated) No. of Female Employees: 1459 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
GU2292000

[ HS Code ]:
29400090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 29400090

Articles

Photoreversible polymer-surfactant micelles using the molecular recognition of α-cyclodextrin.

Langmuir 29(10) , 3188-94, (2013)

Photoreversible micelles were achieved by a combination of commercially available components sodium alginate (Alg), tetradecyltrimethylammonium bromide (TTAB), α-cyclodextrin (α-CD), and 4-(phenylazo)...

An intelligent anticorrosion coating based on pH-responsive supramolecular nanocontainers.

Nanotechnology 23(50) , 505705, (2012)

The hollow mesoporous silica nanoparticles (HMSNs), which have been used as the nanocontainers for the corrosion inhibitor, benzotriazole, were fabricated using the hard-template method. Alkaline-resp...

Beads made of α-cyclodextrin and soybean oil: the drying method influences bead properties and drug release.

Drug Dev. Ind. Pharm. 39(9) , 1306-14, (2013)

Freeze-dried beads made of α-cyclodextrin and soybean oil were reported previously as an efficient system for the oral delivery of lipophilic drugs. In the present study, oven-drying was evaluated as ...