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Rosiridin

Names

[ CAS No. ]:
100462-37-1

[ Name ]:
Rosiridin

[Synonym ]:
Rosiridin
(2E)-4-Hydroxy-3,7-dimethyl-2,6-octadien-1-yl β-D-glucopyranoside
X1221
(2E,4S)-4-Hydroxy-3,7-dimethyl-2,6-octadien-1-yl beta-D-glucopyranoside
β-D-Glucopyranoside, (2E)-4-hydroxy-3,7-dimethyl-2,6-octadien-1-yl

Biological Activity

[Description]:

Rosiridin, which is isolated from Rhodiola rosea L., inhibits MAO A and MAO B with potential beneficial effect in depression and senile dementia. Rosiridin shows an inhibition of 83.8% against MAO B at 10 μM (pIC50=5.38)[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase
Research Areas >> Neurological Disease

[Target]

pIC50: 5.38 (MAO B)[1]


[In Vitro]

Rosiridin presents an inhibition 16.2±2.3 and 83.8±1.1% on MAO A and MAO B at a concentration of 10 μM[1].

[References]

[1]. van Diermen D, et al. Monoamine oxidase inhibition by Rhodiola rosea L. roots. J Ethnopharmacol. 2009 Mar 18;122(2):397-401.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
563.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H28O7

[ Molecular Weight ]:
332.389

[ Flash Point ]:
294.6±30.1 °C

[ Exact Mass ]:
332.183502

[ PSA ]:
119.61000

[ LogP ]:
-0.11

[ Vapour Pressure ]:
0.0±3.5 mmHg at 25°C

[ Index of Refraction ]:
1.555

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route