MX69

MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.

Signaling Pathways >> Apoptosis >> IAP

Signaling Pathways >> Apoptosis >> MDM-2/p53

Research Areas >> Cancer

MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro[1].

MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo[1].

[1]. Gu L, et al. Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer Cell. 2016 Oct 10;30(4):623-636

LCL161 | Pifithrin-α hydrobromide | RG7388 | Birinapant | Nutlin-3a | AMG232 | BV-6 | AZD5582 | Pifithrin-β (hydrobromide) | Stylomycin aminonucleoside | RG7112 | SM-164 | GDC-0152 | APR-246 | NVP-HDM201