Bis-Mal-PEG3

Names

[ Name ]:
Bis-Mal-PEG3

[Synonym ]:
N,N'-[Oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamide]
1H-Pyrrole-1-propanamide, N,N'-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis[2,5-dihydro-2,5-dioxo-

Biological Activity

[Description]:

Bis-Mal-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
791.7±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₃₀N₄O₉

[ Molecular Weight ]:
494.495

[ Flash Point ]:
432.6±32.9 °C

[ Exact Mass ]:
494.201294

[ LogP ]:
-2.61

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.549

Bis-Mal-PEG3

Names

Biological Activity

Chemical & Physical Properties

Related Compounds