NA-CBZ-ARG-ARG 4-METHOXY-B-NAPHTHYLAMIDE

Names

[ Name ]:
NA-CBZ-ARG-ARG 4-METHOXY-B-NAPHTHYLAMIDE

[Synonym ]:
Z-Arg-Arg 4-methoxy-|A-naphthylamide acetate salt

Biological Activity

[Description]:

Z-Arg-Arg-4MβNA triacetate is a cathepsin B-specific substrate and can produce fluorescent end product 4MβNA (λex = 355 nm, λem = 430 nm)[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[Target]

Cathepsin B

[References]

[1]. Büth H, et al. HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration. Eur J Cell Biol. 2004 Dec;83(11-12):781-95.

[2]. van den Bos T, et al. Differences in matrix composition between calvaria and long bone in mice suggest differences in biomechanical properties and resorption: Special emphasis on collagen. Bone. 2008 Sep;43(3):459-68.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₃H₄₅N₉O₇

[ Molecular Weight ]:
679.76600

[ Exact Mass ]:
679.34400

[ PSA ]:
277.33000

[ LogP ]:
6.26020

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H351

[ Precautionary Statements ]:
P281

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
40

[ Safety Phrases ]:
22-36

[ RIDADR ]:
NONH for all modes of transport

Articles

A simple, economical method for staining gels for cathepsin B-like activity.

Anal. Biochem. 119 , 148, (1982)

In vivo and in vitro evidence for the involvement of cysteine proteinases in bone resorption.

Biochem. Biophys. Res. Commun. 125 , 441, (1984)

The excretion of cathepsin B, a lysosomal cysteine proteinase, by parathyroid hormone-stimulated embryonic mouse calvaria in culture, correlates closely with the extent of bone resorption evaluated by...