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[D-Trp2,7,9]-Substance P

Names

[ CAS No. ]:
100930-11-8

[ Name ]:
[D-Trp2,7,9]-Substance P

[Synonym ]:
(d-trp2,7,9)-substance p
arg-d-trp-lys-pro-gln-gln-d-trp-phe-d-trp-leu-met-nh2
h-arg-d-trp-lys-pro-gln-gln-d-trp-phe-d-trp-leu-met-nh2

Biological Activity

[Description]:

[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist with Ki values of 1 μM, 1.3 μM, and ~9 μM for NK-1, NK-2,and NK-3 receptor, respectively[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[Target]

NK1:1 μM (Ki)

NK2:1.3 μM (Ki)

NK3:~9 μM (Ki)


[References]

[1]. S H Buck, et al. Agonist and antagonist binding to tachykinin peptide NK-2 receptors. Life Sci. 1988;42(26):2701-8.  

Chemical & Physical Properties

[ Molecular Formula ]:
C80H109N21O13S

[ Molecular Weight ]:
1604.92000

[ Exact Mass ]:
1603.82000

[ PSA ]:
598.09000

[ LogP ]:
8.43880

Related Compounds