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RTIL 13

Names

[ CAS No. ]:
1009376-10-6

[ Name ]:
RTIL 13

Biological Activity

[Description]:

RTIL 13 is a potent inhibitor of dynamin GTPase, with an IC50 of 2.3 µM for dynamin I GTPase. RTIL 13 also targets pleckstrin homology lipid binding domain. RTIL 13 can inhibit receptor-mediated and synaptic vesicle endocytosis, with IC50s of 9.3 μM and 7.1 μM, respectively[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras
Research Areas >> Neurological Disease

[Target]

IC50: 2.3 µM (dynamin I GTPase)[1]


[In Vitro]

RTIL 13 inhibits receptor-mediated and synaptic vesicle endocytosis, with IC50s of 9.3 μM and 7.1 μM, respectively[2].

[References]

[1]. Zhang J, et, al. From Spanish fly to room-temperature ionic liquids (RTILs): synthesis, thermal stability and inhibition of dynamin 1 GTPase by a novel class of RTILs. New Journal of Chemistry. 2008 Jan; 32(1): 1-180.

[2]. Ascent Scientific Launch Novel Dynamin Inhibitor Dyngo-4a™ with Children's Medical Research Institute and University of Newcastle. Tuesday, December 28, 2021.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H55BrN2O3

[ Molecular Weight ]:
571.67

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds