CY 208-243

Names

[ CAS No. ]:
100999-26-6

[ Name ]:
CY 208-243

[Synonym ]:
SynaptoRedTM C2

Biological Activity

[Description]:

CY 208-243 is a selective dopamine D1 receptor agonist which exhibits antiparkinsonian activity[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[Target]

dopamine D1 receptor[1]

[In Vivo]

Pretreatment with CY 208-243 (2.5 mg/kg; s.c.) prevents the increase of DA release and metabolism induced by the D-1 antagonist, SCH 23390 (0.05 mg/kg; s.c.)[1]. Animal Model: Male Sprague-Dawley rats (180-200 g)[1] Dosage: 2.5 mg/kg Administration: Subcutaneous Result: Prevented the increase of DA release and metabolism induced by the D-1 antagonist.

[References]

[1]. Imperato A, et al. CY 208-243, a novel dopamine D-1 receptor agonist, fails to modify dopamine release in freely moving rats. Eur J Pharmacol. 1989 Jan 24;160(1):155-8.

[2]. Temlett JA, et al. The D-1 dopamine receptor partial agonist, CY 208-243, exhibits antiparkinsonian activity in the MPTP-treated marmoset. Eur J Pharmacol. 1988 Nov 1;156(2):197-206.

Chemical & Physical Properties

[ Density]:
1.225 g/cm3

[ Boiling Point ]:
466.5ºC at 760 mmHg

[ Melting Point ]:
227-228ºC

[ Molecular Formula ]:
C₁₉H₁₈N₂

[ Molecular Weight ]:
274.36000

[ Flash Point ]:
236ºC

[ Exact Mass ]:
274.14700

[ PSA ]:
19.03000

[ LogP ]:
3.60780

[ Vapour Pressure ]:
7.02E-09mmHg at 25°C

[ Index of Refraction ]:
1.697

CY 208-243

Names

Biological Activity

Chemical & Physical Properties

Precursor & DownStream

Precursor

DownStream

Related Compounds