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Desethyl KBT-3022

Names

[ CAS No. ]:
101001-72-3

[ Name ]:
Desethyl KBT-3022

[Synonym ]:
1H-Pyrrole-1-aceticacid,2-[4,5-bis(4-methoxyphenyl)-2-thiazolyl]
Desethyl KB 3022
2-(4,5-Bis(4-methoxylphenyl)thiazol-2-yl)pyrrol-1-ylacetic acid
Desethyl kbt-3022

Biological Activity

[Description]:

Desethyl KBT-3022 is the main active metabolite of the new antiplatelet agent, KBT-3022.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin
Research Areas >> Cardiovascular Disease

[In Vitro]

Pretreatment with desethyl KBT-3022 0.1, 0.3 and 1 mg/kg, i.v. prolongs the time required to achieve thrombotic occlusion in the femoral artery and inhibits collagen-induced platelet aggregation in whole blood ex vivo, each in a dose-dependent manner. Desethyl KBT-3022 inhibits the thrombin-induced aggregation of washed platelets in a concentration-dependent manner 1–40 μM[1].

[References]

[1]. Shimazawa M, et al. Antithrombotic effects in a rat model of aspirin-insensitive arterial thrombosis of desethyl KBT-3022, the main active metabolite of a new antiplatelet agent, KBT-3022. Eur J Pharmacol. 1997 Jun 11;328(2-3):183-9.


[Related Small Molecules]

AEBSF HCl | Bivalirudin trifluoroacetate salt | Thrombin | Metolazone | Inogatran | Napsagatran hydrate | NQ 301 | RWJ-445167 | OM-189 | TRAP-14 trifluoroacetate salt | Thrombin inhibitor 1

Chemical & Physical Properties

[ Density]:
1.29g/cm3

[ Boiling Point ]:
630.3ºC at 760mmHg

[ Molecular Formula ]:
C23H20N2O4S

[ Molecular Weight ]:
420.48100

[ Flash Point ]:
335ºC

[ Exact Mass ]:
420.11400

[ PSA ]:
101.82000

[ LogP ]:
5.04740

[ Vapour Pressure ]:
9.4E-17mmHg at 25°C

[ Index of Refraction ]:
1.642

Related Compounds