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Kushenol M

Names

[ CAS No. ]:
101236-51-5

[ Name ]:
Kushenol M

[Synonym ]:
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-6-(3-methyl-2-buten-1-yl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2R,3R)-
(2R,3R)-2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2R)-2-isopropenyl-5-methyl-4-hexen-1-yl]-6-(3-methyl-2-buten-1-yl)-2,3-dihydro-4H-chromen-4-one

Biological Activity

[Description]:

Kushenol M is a flavonoid from Sophora flavescens. Kushenol M is a cytochrome P450 (CYP) inhibitor, with IC50 values of 1.29 μM for CYP3A4 in in human liver microsomes[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Research Areas >> Others

[References]

[1]. Xinguang Liu, et al. Advances in Metabolic Profiling and Pharmacokinetics of Herbal Medicinal Products. Evid Based Complement Alternat Med. 2019 May 6;2019:5190972.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
737.7±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H36O7

[ Molecular Weight ]:
508.603

[ Flash Point ]:
240.1±26.4 °C

[ Exact Mass ]:
508.246094

[ LogP ]:
7.84

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.619

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds