gadolinium chloride

Gadolinium chloride is a specific calcium-sensing receptor (CaSR) agonist. Gadolinium chloride can be used for the research of cardiovascular disease[1].

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> CaSR

CaSR[1]

Gadolinium chloride (30 μM; 15 minutes; H9c2 cells) results in increased Bax expression and caspase-3 activation, and decreased Bcl-2 expression in CsA-induced cells[1]. In vitro, GdCl3, a CaSR agonist, has been shown to promote the apoptosis of myocardial cells, which increases ERK1/2 phosphorylation and activates caspase-3[1]. Western Blot Analysis[1] Cell Line: H9c2 cells Concentration: 30 μM Incubation Time: 15 minutes Result: Resulted in increased Bax expression and caspase-3 activation, and decreased Bcl-2 expression in CsA-induced cells.

[1]. Li X, et al. Calcium Oxalate Induces Renal Injury through Calcium-Sensing Receptor. Oxid Med Cell Longev. 2016;2016:5203801.

MOLECULAR FORMULA :

Cl3-Gd

MOLECULAR WEIGHT :

263.60

WISWESSER LINE NOTATION :

GD G3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

REFERENCE :

BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,526,1961

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

REFERENCE :

BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,526,1961 ** ACUTE TOXICITY DATA **

TYPE OF TEST :

LD - Lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

>2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,526,1961

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

378 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Lungs, Thorax, or Respiration - other changes

REFERENCE :

AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 5,437,1962 *** REVIEWS *** TOXICOLOGY REVIEW JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 54,663,1965