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CP 376395 hydrochloride

Names

[ CAS No. ]:
1013933-37-3

[ Name ]:
CP 376395 hydrochloride

[Synonym ]:
Remoxipride hydrochloride

Biological Activity

[Description]:

CP 376395 hydrochloride is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist[1][2].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> CRFR

Research Areas >> Neurological Disease

[Target]

CRFR1

CRFR2

[References]

[1]. Chen YL, et al. 2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J Med Chem. 2008 Mar 13;51(5):1385-92.

[2]. Giardino WJ, et al. CRF1 receptor signaling regulates food and fluid intake in the drinking-in-the-dark model of binge alcohol consumption. Alcohol Clin Exp Res. 2013 Jul;37(7):1161-70.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₃₁ClN₂O

[ Molecular Weight ]:
362.94

[ Exact Mass ]:
362.21200

[ PSA ]:
34.15000

[ LogP ]:
6.89140

Related Compounds