Methyl salvionolate A

Names

[ Name ]:
Methyl salvionolate A

[Synonym ]:
(2R)-3-(3,4-Dihydroxyphenyl)-1-methoxy-1-oxo-2-propanyl (2E)-3-{2-[(E)-2-(3,4-dihydroxyphenyl)vinyl]-3,4-dihydroxyphenyl}acrylate
Benzenepropanoic acid, α-[[(2E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-, methyl ester, (αR)-
Methyl salvionolate A

Biological Activity

[Description]:

Methyl salvionolate A is a potent inhibitor of HIV-1. Methyl salvionolate A inhibits P24 antigen in HIV-1 infected MT-4 cell with an EC50 of 1.62 μg/ml. Methyl salvionolate A also inhibits HIV-1 reverse transcriptase, protease and integrase with IC50s of 50.58, 10.73 and 7.58 μg/ml, respectively[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

[References]

[1]. Wang Q, et al. Salviachinensines A-F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis. J Nat Prod. 2018 Nov 26;81(11):2531-2538.

[2]. Zhang ZF, et al. Three new derivatives of anti-HIV-1 polyphenols isolated from Salvia yunnanensis. J Asian Nat Prod Res. 2008 May-Jun;10(5-6):391-6.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
824.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₇H₂₄O₁₀

[ Molecular Weight ]:
508.474

[ Flash Point ]:
278.2±27.8 °C

[ Exact Mass ]:
508.136932

[ LogP ]:
4.65

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.747

[ Water Solubility ]:
Insuluble (5.6E-3 g/L) (25 ºC)

Methyl salvionolate A

Names

Biological Activity

Chemical & Physical Properties

Related Compounds