SARS-CoV-2-IN-31

Names

[ CAS No. ]:
1017691-52-9

[ Name ]:
SARS-CoV-2-IN-31

Biological Activity

[Description]:

SARS-CoV-2-IN-31 is an effective COVID-19 inhibitor. SARS-CoV-2-IN-31 exhibits excellent to mild activity against various cancer cell lines with IC50 values range from 28.84 to 38.36 μM. SARS-CoV-2-IN-31 can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

IC50: 38.36 μM (MCF-7); 38.46 μM (MDA-MB-231); 28.84 μM (HeLa); 30.62 μM (PC-3); ＞40 μM (Ishikawa)[1]


[In Vitro]

SARS-CoV-2-IN-31 exhibits antiproliferative activity in five different human cancer cell lines with IC50 values of 38.36 μM (MCF-7), 38.46 μM (MDA-MB-231), 28.84 μM (HeLa), 30.62 μM (PC-3) and ＞40 μM (Ishikawa), respectively[1]. SARS-CoV-2-IN-31 shows comparatively high binding affinity with value of -8.3 Kcal/mole[1]

[References]

[1]. Anamika Gupta, et al. Visible Light-Promoted Green and Sustainable Approach for One-Pot Synthesis of 4,4’-(Arylmethylene)bis(1H-pyrazol-5-ols), In Vitro Anticancer Activity, and Molecular Docking with Covid-19 Mpro. ACS Omega 2022.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H28N4O2

[ Molecular Weight ]:
464.56

Related Compounds