Phenylbiguanide
Names
[ CAS No. ]:
102-02-3
[ Name ]:
Phenylbiguanide
[Synonym ]:
N-Phenyliminodicarbonimidic Diamide
Phenylbiguanide
MFCD00179077
1-(diaminomethylidene)-2-phenylguanidine
EINECS 202-998-5
Biological Activity
[Description]:
[Related Catalog]:
[Target]
5-HT3 Receptor:3 μM (EC50)
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.33g/cm3
[ Boiling Point ]:
388.4ºC at 760mmHg
[ Melting Point ]:
135-142 °C(lit.)
[ Molecular Formula ]:
C8H11N5
[ Molecular Weight ]:
177.20600
[ Flash Point ]:
188.7ºC
[ Exact Mass ]:
177.10100
[ PSA ]:
100.28000
[ LogP ]:
1.88000
[ Vapour Pressure ]:
3.08E-06mmHg at 25°C
[ Index of Refraction ]:
1.656
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DU2450000
- CHEMICAL NAME :
- Biguanide, 1-phenyl-
- CAS REGISTRY NUMBER :
- 102-02-3
- LAST UPDATED :
- 198505
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C8-H11-N5
- MOLECULAR WEIGHT :
- 177.24
- WISWESSER LINE NOTATION :
- MUYZMYUM&MR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 16,267,1967
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
DU2450000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
J. Physiol. 593(7) , 1715-29, (2015)
The nucleus tractus solitarii (NTS) integrates inputs from cardiovascular afferents and thus is crucial for cardiovascular homeostasis. These afferents primarily release glutamate, although 5-HT has a...
Microvascular dilation evoked by chemical stimulation of C-fibers in rats.J. Appl. Physiol. 118(1) , 55-60, (2015)
Activation of pulmonary C-fibers can reflexively decrease heart rate, blood pressure, and peripheral vascular resistance. However, the effects of these afferents on microvascular tone remain incomplet...
5-HT1D receptor inhibits renal sympathetic neurotransmission by nitric oxide pathway in anesthetized rats.Vascul. Pharmacol. 72 , 172-80, (2015)
Although serotonin has been shown to inhibit peripheral sympathetic outflow, serotonin regulation on renal sympathetic outflow has not yet been elucidated. This study investigated which 5-HT receptor ...