baquiloprim

Names

[ Name ]:
baquiloprim

[Synonym ]:
5-{[8-(Dimethylamino)-7-methyl-5-quinolinyl]methyl}-2,4-pyrimidinediamine
baquiloprim
2,4-Pyrimidinediamine, 5-[[8-(dimethylamino)-7-methyl-5-quinolinyl]methyl]-
5-((2,4-Diamino-5-pyrimidinyl)methyl)-8-(dimethylamino)-7-methylquinoline

Biological Activity

[Description]:

Baquiloprim, an antibiotic, is a selective inhibitor of bacterial dihydrofolate reductases. Baquiloprim possesses in vitro bacteriostatic activity against both Gram-negative and Gram-positive bacteria[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Lewicki J, et, al. Oral bioavailability and pharmacokinetics of baquiloprim in dwarf goats. Res Vet Sci. 1995 May;58(3):268-71.

[2]. White DG, et, al. Comparison of danofloxacin with baquiloprim/sulphadimidine for the treatment of experimentally induced Escherichia coli diarrhoea in calves. Vet Rec. 1998 Sep 5;143(10):273-6.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
567.9±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₀N₆

[ Molecular Weight ]:
308.381

[ Flash Point ]:
297.2±32.9 °C

[ Exact Mass ]:
308.174957

[ PSA ]:
93.95000

[ LogP ]:
2.32

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.719

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
UV8142576

Articles

Eimeria alabamensis coccidiosis in grazing calves: control by a long-acting baquiloprim/sulphadimidine bolus.

Appl. Parasitol. 37(3) , 168-76, (1996)

The excretion of Eimeria oocysts, the faecal dry matter and the weight gain of three groups of 12 calves, were compared during their first 20 days of grazing on a pasture known to have been contaminat...

Oral bioavailability and pharmacokinetics of baquiloprim in dwarf goats.

Res. Vet. Sci. 58(3) , 268-71, (1995)

The pharmacokinetics of baquiloprim at a dose of 8 mg kg-1 bodyweight were determined after its intravenous and intra-ruminal administration to seven healthy female dwarf goats. After intravenous inje...

Prevention of Eimeria alabamensis coccidiosis by a long-acting baquiloprim/sulphadimidine bolus.

Vet. Parasitol. 74(2-4) , 143-52, (1998)

Twelve calves aged 6-10 months, and 12 calves aged 10-16 months were turned out onto a permanent pasture known to have been contaminated with oocysts of Eimeria alabamensis during the previous year. T...