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Olaratumab

Names

[ CAS No. ]:
1024603-93-7

[ Name ]:
Olaratumab

Biological Activity

[Description]:

Olaratumab (IMC-3G3; LY3012207) is an anti-platelet-derived growth factor receptor alpha (PDGFRα) human monoclonal IgG1 antibody with antitumor activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR

[In Vitro]

IMC-3G3 (100 μg/mL, 72 h) 阻断了SKOV3-ip1 细胞的 PDGFRα 磷酸化。并且 IMC-3G3 和多西他赛联合治疗时在 SKOV3-ip1 和 HeyA8 两种细胞系中显著诱导了凋亡[1]。

[In Vivo]

IMC-3G3 (i.p., 40 mg/kg, three times per week, 6 weeks)在 SKOV3-ip1 荷瘤小鼠中，与对照组相比，IMC-3G3 单独处理没有明显的抗肿瘤作用，而在 HeyA8 荷瘤小鼠中，IMC-3G3 单药治疗与对照组相比显示出显著的抗肿瘤作用，肿瘤减少率为 62%[1]。

[References]

[1]. Koji Matsuo, et al. Platelet-derived growth factor receptor alpha (PDGFRα) targeting and relevant biomarkers in ovarian carcinoma. Gynecol Oncol. 2014 Jan;132(1):166-75.   

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds