SC-9

Names

[ CAS No. ]:
102649-78-5

[ Name ]:
SC-9

[Synonym ]:
5-chloro-N-(6-phenylhexyl)naphthalene-1-sulfonamide
MFCD00065544

Biological Activity

[Description]:

SC-9 is a PKC activator in the presence of Ca2+[1][2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC

Research Areas >> Endocrinology

Signaling Pathways >> TGF-beta/Smad >> PKC

[References]

[1]. Ito M, et al. N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide, a novel activator of protein kinase C. Biochemistry. 1986 Jul 29;25(15):4179-84.

[2]. Nishino H, et al. N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide is one of a new class of activators for Ca2+-activated, phospholipid-dependent protein kinase. Biochim Biophys Acta. 1986 Nov 28;889(2):236-9.

Chemical & Physical Properties

[ Density]:
1.22g/cm3

[ Boiling Point ]:
577.5ºC at 760 mmHg

[ Melting Point ]:
75-76ºC

[ Molecular Formula ]:
C₂₂H₂₄ClNO₂S

[ Molecular Weight ]:
401.94900

[ Flash Point ]:
303.1ºC

[ Exact Mass ]:
401.12200

[ PSA ]:
54.55000

[ LogP ]:
7.04630

[ Vapour Pressure ]:
2.46E-13mmHg at 25°C

[ Index of Refraction ]:
1.609

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2935009090

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

Stimulation of choline transport in cultured cells induced by 12-O-tetradecanoylphorbol-13-acetate: one of the earliest phenomena induced by the tumor promoter.

Oncology 45(4) , 326-30, (1988)

12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter, stimulated membrane transport of choline in cultured cells. This is one of the earliest phenomena caused by tumor promoter. 4-O-met...

N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide is one of a new class of activators for Ca2+-activated, phospholipid-dependent protein kinase.

Biochim. Biophys. Acta 889 , 236, (1986)

N-(6-Phenylhexyl)-5-chloro-1-naphthalenesulfonamide (SC-9) activated Ca2+-activated, phospholipid-dependent protein kinase (protein kinase C). SC-9 acted as a substitute for phosphatidylserine, which ...

N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide, a novel activator of protein kinase C.

Biochemistry 25 , 4179, (1986)

Naphthalenesulfonamide derivatives were used to study the mechanism of regulation of Ca2+-dependent smooth muscle myosin light chain phosphorylation catalyzed by Ca2+-activated, phospholipid-dependent...