2-Butenoyl coenzyme A lithium

Names

[ Name ]:
2-Butenoyl coenzyme A lithium

[Synonym ]:
[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-2-[[[[4-[[3-[2-[(E)-but-2-enoyl]sulfanylethylamino]-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutoxy]-oxidophosphoryl]oxy-oxidophosphoryl]oxymethyl]-4-hydroxyoxolan-3-yl] phosphate

Biological Activity

[Description]:

2-Butenoyl coenzyme A (lithium), an active compound, can be used as a substrate for plasmodium falciparum enyl-ACP reductases and other enyl-CoA reductases. 2-Butenoyl coenzyme A lithium can be used as a substrate analogue to study the kinetics of β-hydroxyacyl-acyl-carrier protein (ACP) dehydratase (FabZ)[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Weizhi Liu, et al. A new beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Helicobacter pylori: Molecular cloning, enzymatic characterization, and structural modeling. Biochem Biophys Res Commun. 2005 Aug 12;333(4):1078-86.

Chemical & Physical Properties

[ Density]:
1.82g/cm3

[ Molecular Formula ]:
C₂₅H₄₀N₇O₁₇P₃S

[ Molecular Weight ]:
835.60800

[ Exact Mass ]:
835.14100

[ PSA ]:
425.34000

[ LogP ]:
1.50260

[ Index of Refraction ]:
1.7

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Kinetic and structural analysis of the increased affinity of enoyl-ACP (acyl-carrier protein) reductase for triclosan in the presence of NAD+.

Biochem. J. 381 , 725-733, (2004)

The binding of enoyl-ACP (acyl-carrier protein) reductase from Plasmodium falciparum (PfENR) with its substrates and inhibitors has been analysed by SPR (surface plasmon resonance). The binding of the...

A novel prokaryotic trans-2-enoyl-CoA reductase from the spirochete Treponema denticola.

FEBS Lett. 581 , 1561-1566, (2007)

An NADH-dependent trans-2-enoyl-CoA reductase (EC1.1.1.36) from the Gram negative spirochete Treponema denticola was identified, expressed and biochemically characterized. The recombinant protein is a...

A new beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Helicobacter pylori: Molecular cloning, enzymatic characterization, and structural modeling.

Biochem. Biophys. Res. Commun. 333 , 1078-1086, (2005)

Helicobacter pylori is a gram-negative pathogenic bacterium that causes peptic ulcer disease and gastric cancer, and studies of the related potent enzymes associated with this bacterium are urgent for...