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Nanterinone

Names

[ CAS No. ]:
102791-47-9

[ Name ]:
Nanterinone

[Synonym ]:
6-(2,4-dimethylimidazol-1-yl)-8-methyl-2(1H)-quinolinone
6-(2,4-dimethyl-1h-imidazol-1-yl)-8-methylquinolin-2-ol
8-Methyl-6-(2,4-dimethylimidazol-1-yl)-2(1H)-quinazolinone
2(1H)-Quinolinone,6-(2,4-dimethyl-1H-imidazol-1-yl)-8-methyl
Nanterinone
UK-61,260
6-(2,4-dimethylimidazol-1-yl)-8-methyl-2-(1H)-quinolone

Biological Activity

[Description]:

Nanterinone (UK 61260) is a positive inotropic and arterial vasodilating agent. Nanterinone is a phosphodiesterase inhibitor[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

[References]

[1]. Remme WJ, et al. Acute hemodynamic effects and preload-dependent cardiovascular profile of the partial phosphodiesterase inhibitor nanterinone in patients with mild to moderate heart failure. Cardiovasc Drugs Ther. 1996 May;10(2):137-44.  

Chemical & Physical Properties

[ Density]:
1.24g/cm3

[ Molecular Formula ]:
C15H15N3O

[ Molecular Weight ]:
253.29900

[ Exact Mass ]:
253.12200

[ PSA ]:
50.94000

[ LogP ]:
3.05130

[ Index of Refraction ]:
1.651

Related Compounds