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Intermedine

Names

[ CAS No. ]:
10285-06-0

[ Name ]:
Intermedine

[Synonym ]:
[(7R,8R)-7-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl (2S)-2-hydroxy-2-[(1R)-1-hydroxyethyl]-3-methylbutanoate
Intermedina [INN-Spanish]
Butanoic acid,2,3-dihydroxy-2-(1-methylethyl)-,((1R,7aR)-2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl)methyl ester,(2S,3R)
9-(+)-Trachelanthylretronecine
lycopsamine
Intermedine
Intermedinum [INN-Latin]
[(1r,7ar)-1-hydroxy-2,3,5,7a-tetrahydro-1h-pyrrolizin-7-yl]methyl(2s,3r)-2,3-dihydroxy-2-(propan-2-yl)butanoate
Intermedina
Intermedinum

Biological Activity

[Description]:

(+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs)[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[In Vitro]

(+)-Intermedine (1.1-30 μM; 24 hours) exhibits significant cytotoxicity at 30 μM and reduces cell viability in a concentration dependent manner in neural progenitor cells (NPCs)[1]. (+)-Intermedine showsno differentiation impairment[1]. Cell Cytotoxicity Assay[1] Cell Line: Neural progenitor cells (NPCs) Concentration: 1.1, 3.3, 10, 30 μM Incubation Time: 24 hours Result: Exhibited significant cytotoxicity at 30 μM and reduced cell viability in a concentration dependent manner.

[References]

[1]. Yan Zhang, et al. Analysis of pyrrolizidine alkaloids in Eupatorium fortunei Turcz. and their in vitro neurotoxicity. Food Chem Toxicol. 2021 May;151:112151.

Chemical & Physical Properties

[ Density]:
1.26g/cm3

[ Boiling Point ]:
463.3ºC at 760mmHg

[ Molecular Formula ]:
C15H25NO5

[ Molecular Weight ]:
299.36300

[ Flash Point ]:
234ºC

[ Exact Mass ]:
299.17300

[ PSA ]:
90.23000

[ Vapour Pressure ]:
1.57E-10mmHg at 25°C

[ Index of Refraction ]:
1.567

Safety Information

[ RIDADR ]:
UN 1544

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Related Compounds