Benzyl cinnamate

Names

[ CAS No. ]:
103-41-3

[ Name ]:
Benzyl cinnamate

[Synonym ]:
Cinnamic Acid Benzyl Ester
benzyl trans-3-phenylpropenoate
2-Propenoic acid, 3-phenyl-, phenylmethyl ester, (E)-
FEMA 2142
Benzyl (2E)-3-phenyl-2-propenoate
benzyl (2E)-3-phenylprop-2-enoate
Benzyl Alcohol Cinnamate
2-Propenoic acid, 3-phenyl-, phenylmethyl ester, (2E)-
Benzyl cinnamate
Benzyl γ-phenylacrylate
EINECS 203-109-3
Benzyl ciamate
CINNAMEIN
benzylalcohol,cinnamate
Phenylmethyl cinnamate
Benzyl g-Phenylacrylate
MFCD00004789
Benzyl (2E)-3-phenylacrylate

Biological Activity

[Description]:

Benzyl cinnamate, occurs in Balsam of Peru and Tolu balsam, in Sumatra and Penang benzoin, and as the main constituent of copaiba balsam, is used in heavy oriental perfumes and as a fixative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Bhatia SP, et al. Fragrance material review on benzyl cinnamate. Food Chem Toxicol. 2007;45 Suppl 1:S40-8. Epub 2007 Sep 14.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
195-200 ºC (5 mmHg)

[ Melting Point ]:
34-37 °C(lit.)

[ Molecular Formula ]:
C₁₆H₁₄O₂

[ Molecular Weight ]:
238.281

[ Flash Point ]:
225.7±10.4 °C

[ Exact Mass ]:
238.099380

[ PSA ]:
26.30000

[ LogP ]:
3.65

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.4025-1.4045

[ Water Solubility ]:
PRACTICALLY INSOLUBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GD8400000

CHEMICAL NAME :: Cinnamic acid, benzyl ester

CAS REGISTRY NUMBER :: 103-41-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C16-H14-O2

MOLECULAR WEIGHT :: 238.30

WISWESSER LINE NOTATION :: R1U1VO1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,1017,1973 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5530 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - coma

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3760 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - gastritis

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83174 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 456 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83174 No. of Facilities: 546 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 2855 (estimated) No. of Female Employees: 1107 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
3077

[ WGK Germany ]:
2

[ RTECS ]:
GD8400000

[ HS Code ]:
29163900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 29163900

Articles

Novel natural product-based cinnamates and their thio and thiono analogs as potent inhibitors of cell adhesion molecules on human endothelial cells.

Eur. J. Med. Chem. 46 , 5498-511, (2011)

In the present study, we report the design and synthesis of novel analogs of cinnamates, thiocinnamates and thionocinnamates and evaluated the potencies of these analogs to inhibit TNF-α induced ICAM-...

Determination of UV filters and antimicrobial agents in environmental water samples.

Anal. Bioanal. Chem 387(4) , 1343-50, (2007)

Although there is increasing concern about residues from personal care products entering the aquatic environment and their potential to accumulate to levels that pose a health threat to humans and wil...

Study on the constituents of Mexican propolis and their cytotoxic activity against PANC-1 human pancreatic cancer cells.

J. Nat. Prod. 73 , 623-7, (2010)

Three new flavonoids, (2R,3R)-3,5-dihydroxy-7-methoxyflavanone 3-(2-methyl)butyrate (1), (7''R)-8-[1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl]chrysin (2), and (7''R)-8-[1-(4'-hydroxy-3'-methoxyphen...