<Suppliers Price>

MC-70

Names

[ CAS No. ]:
1031367-64-2

[ Name ]:
MC-70

[Synonym ]:
4'-[(6,7-Dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl)methyl]-4-biphenylol
4'-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol; MC70
4'-[(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methyl]biphenyl-4-ol
[1,1'-Biphenyl]-4-ol, 4'-[(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)methyl]-

Biological Activity

[Description]:

MC70 is a potent and non-selective P-glycoprotein (P-gp) inhibitor with an EC50 of 0.69 µM. MC70 is an ABC transporters inhibitor and anticancer agent. MC70 interacts with ABCB1, ABCG2 and ABCC1[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein

[Target]

EC50: 0.69 µM (P-glycoprotein)[1]


[References]

[1]. Stefano Guglielmo, et al. Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4'-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein. J Med Chem. 2016 Jul 28;59(14):6729-38.

[2]. Amalia Azzariti, et al. MC70 potentiates doxorubicin efficacy in colon and breast cancer in vitro treatment. Eur J Pharmacol. 2011 Nov 16;670(1):74-84.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
536.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H25NO3

[ Molecular Weight ]:
375.46

[ Flash Point ]:
278.3±30.1 °C

[ Exact Mass ]:
375.183441

[ LogP ]:
4.22

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.617

Related Compounds