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L-655,240

Names

[ CAS No. ]:
103253-15-2

[ Name ]:
L-655,240

[Synonym ]:
N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu
L-655,240
Lopac-L-9539
Tocris-1698

Biological Activity

[Description]:

L 655240 is thromboxane antagonist. L 655240 attenuates early ischemia- and reperfusion-induced arrhythmias in a canine model of coronary artery occlusion. L 655240 also involves in cancer and autoimmune disorders[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

[In Vitro]

L 655240 (7 nM) 抑制人血小板中内过氧化物诱导的聚集[1]。

[In Vivo]

L 655240 (0.3 mg/kg；静脉注射；单次剂量) 改变犬类模型的发热率、动脉和肺动脉血压以及心输出量[1]。

[References]

[1]. Wainwright CL, et al. The effects of L655,240, a selective thromboxane and prostaglandin endoperoxide antagonist, on ischemia- and reperfusion-induced cardiac arrhythmias. J Cardiovasc Pharmacol. 1988 Sep;12(3):264-71.  

Chemical & Physical Properties

[ Density]:
1.22g/cm3

[ Boiling Point ]:
548.7ºC at 760mmHg

[ Molecular Formula ]:
C21H21ClFNO2

[ Molecular Weight ]:
373.84800

[ Flash Point ]:
285.7ºC

[ Exact Mass ]:
373.12400

[ PSA ]:
42.23000

[ LogP ]:
5.44380

[ Vapour Pressure ]:
7.1E-13mmHg at 25°C

[ Index of Refraction ]:
1.581

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S36/37/39

Related Compounds