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TPO agonist 1

Names

[ CAS No. ]:
1033040-23-1

[ Name ]:
TPO agonist 1

[Synonym ]:
1H-Pyrazole-4,5-dione, 1-(3,4-dimethylphenyl)-3-methyl-, 4-[2-[2-hydroxy-3'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]hydrazone], (4E)-
(4E)-2-(3,4-Dimethylphenyl)-4-{[2-hydroxy-3'-(2H-tetrazol-5-yl)-3-biphenylyl]hydrazono}-5-methyl-2,4-dihydro-3H-pyrazol-3-one

Biological Activity

[Description]:

TPO agonist 1 can increase production of platelets by stimulating the TPO receptor in people with chronic ITP. (Idiopathic Thrombocytopenic Purpura)target: TPO receptor agonist1、TPO receptor agonists can be also used in Bone marrow fibrosis2、TPOreceptor agonists can decrease bleeding events and reduced need for adjunctive or rescue treatments.

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Thrombopoietin Receptor
Research Areas >> Cardiovascular Disease

[References]

[1]. Zeng Y et al. TPO receptor agonist for chronic idiopathic thrombocytopenic purpura. Cochrane Database Syst Rev. 2011 Jul 6;(7):CD008235.

[2]. Siegal D et al. Thrombopoietin receptor agonists in primary immune thrombocytopenia. et al. Semin Hematol. 2013 Jan;50 Suppl 1:S18-21


[Related Small Molecules]

Lusutrombopag | avatrombopag

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
703.5±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H22N8O2

[ Molecular Weight ]:
466.495

[ Flash Point ]:
379.3±35.7 °C

[ Exact Mass ]:
466.186584

[ LogP ]:
3.28

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.735

[ Storage condition ]:
2-8℃

Related Compounds