<Suppliers Price>

L-364373

Names

[ CAS No. ]:
103342-82-1

[ Name ]:
L-364373

[Synonym ]:
L-364,373
CCK antagonist synthetic 11
R-L364,373
R-L3

Biological Activity

[Description]:

L-364,373 (R-L3) is a voltage-gated Kv7.1 (KCNQ1)/mink channels activator. L-364,373 activates Iks (slow delayed rectifier potassium current) and shortens action potential duration in guinea pig cardiac myocytes, and suppresses early afterdepolarizations in rabbit ventricular myocytes[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[References]

[1]. Jow F, et al. Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373). Assay Drug Dev Technol. 2006 Aug;4(4):443-50.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H20FN3O

[ Molecular Weight ]:
397.44400

[ Exact Mass ]:
397.15900

[ PSA ]:
48.46000

[ LogP ]:
4.23270

Related Compounds