Saridegib

Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

Signaling Pathways >> Stem Cell/Wnt >> Smo

Research Areas >> Cancer

Smo[1].

Evidence from a genetically engineered mouse model of pancreatic cancer demonstrates that Saridegib (IPI-926) can deplete tumor-associated stromal tissue and increase intratumoral mean vessel density. These changes result in enhanced delivery of concurrently administered systemic agents such as gemcitabine, leading to a decreased tumor burden and prolonged survival in this mouse model[1].

[1]. Ko AH, et al. A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma. Pancreas. 2016 Mar;45(3):370-5.

SAG.HCI | Purmorphamine | LDE225 (NVP-LDE225,Erismodegib) | PF-04449913 | Jervine | LY2940680 | BMS-833923 | LEQ506 | MK-4101 | MRT-83 | PF-5274857