6-Maleimidocaproic acid sulfo-NHS

Names

[ Name ]:
6-Maleimidocaproic acid sulfo-NHS

[Synonym ]:
1H-Pyrrole-1-hexanoicacid,2,5-dihydro-2,5-dioxo-,2,5-dioxo-3-sulfo-1-pyrrolidinyl ester
BICL221

Biological Activity

[Description]:

6-Maleimidocaproic acid sulfo-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₆N₂O₉S

[ Molecular Weight ]:
388.35000

[ Exact Mass ]:
388.05800

[ PSA ]:
163.81000

6-Maleimidocaproic acid sulfo-NHS

Names

Biological Activity

Chemical & Physical Properties

Related Compounds