(22S,24E)-3α,22-Bis(acetyloxy)-5α-lanosta-7,9(11),24-trien-26-oic acid

Names

[ Name ]:
(22S,24E)-3α,22-Bis(acetyloxy)-5α-lanosta-7,9(11),24-trien-26-oic acid

[Synonym ]:
(E)-(5S,6S)-5-Acetoxy-6-((3R,5R,10S,13R,14R,17R)-3-acetoxy-4,4,10,13,14-pentamethyl-2,3,4,5,6,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-hept-2-enoic acid

Biological Activity

[Description]:

Ganoderic acid R is a potent anticancer agent. Ganoderic acid R inhibits the growth by inducing apoptosis on tumor cell line. Ganoderic acid R possesses significant cytotoxicity on a multidrug resistance (MDR) tumor cell line (KB-A-1/Dox) and a sensitive tumor cell line (KB-A-1)[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[In Vitro]

Ganoderic acid R (0-50 µg/mL, 48 h) 在浓度超过 20 µg/mL时通过诱导肿瘤细胞系凋亡来抑制生长[1]。 Apoptosis Analysis[1] Cell Line: KB-A-1/Dox cells Concentration: 0, 25, 50 μg/mL Incubation Time: 48 h Result: Induced the cellular apoptosis, the number of apoptotic cells was increased from 35% to 90% during 48 h.

[References]

[1]. Ouyang J J, et al. Ganoderic Acid Restores the Sensitivity of Multidrug Resistance Cancer Cells to Doxorubicin. Advanced Materials Research, 2014, 834-836:573-576.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₄H₅₀O₆

[ Molecular Weight ]:
554.76

[ Exact Mass ]:
554.36100

[ PSA ]:
89.90000

[ LogP ]:
7.43220