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Esclentic acid

Names

[ CAS No. ]:
103974-74-9

[ Name ]:
Esclentic acid

[Synonym ]:
Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, (2α,3α)-
(2α,3α)-2,3,23-Trihydroxyurs-12-en-28-oic acid
Esclentic acid
dodeca-2c,7t,10t-triene-1,4-diol

Biological Activity

[Description]:

Esculentic acid is a selective COX-2 inhibitor and has anti-inflammatory effect. Esculentic acid is a pentacyclic triterpenoid that can be extracted from the Chinese herb Phytolacca esculenta[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-2[1]


[References]

[1]. Niu X, et al. Esculentic acid, a novel and selective COX-2 inhibitor with anti-inflammatory effect in vivo and in vitro. Eur J Pharmacol. 2014 Oct 5;740:532-8.  

[2]. Niu X, et al. Protective effects of esculentic acid against endotoxic shock in Kunming mice. Int Immunopharmacol. 2014 Nov;23(1):229-35.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
609.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H48O5

[ Molecular Weight ]:
488.70

[ Flash Point ]:
336.4±28.0 °C

[ Exact Mass ]:
488.350189

[ PSA ]:
97.99000

[ LogP ]:
6.46

[ Vapour Pressure ]:
0.0±4.0 mmHg at 25°C

[ Index of Refraction ]:
1.579

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds