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STAT3-IN-8

Names

[ CAS No. ]:
1041438-68-9

[ Name ]:
STAT3-IN-8

[Synonym ]:
Ethyl 1-(4-cyano-2,3,5,6-tetrafluorophenyl)-6,7,8-trifluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylate
3-Quinolinecarboxylic acid, 1-(4-cyano-2,3,5,6-tetrafluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxo-, ethyl ester

Biological Activity

[Description]:

STAT3-IN-5 is a potent STAT3 inhibitor. STAT3-IN-5 inhibits STAT3-Y705 phosphorylation with an EC50 value of 170 nM. STAT3-IN-5 inhibits cytokine induced JAK activation. STAT3-IN-5 induces apoptosis. STAT3-IN-5 can be used in research of cancer[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT
Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> STAT

[Target]

p-STAT3:170 nM (EC50)


[In Vitro]

STAT3-IN-5 (compound 8; 0-2 μM; 1 h) 抑制 U266 细胞中的 STAT3 磷酸化[1]。 STAT3-IN-5 (0-2 μM; 1 h) 抑制 U266 细胞中细胞因子诱导的 JAK1、JAK2 和 Tyk2 磷酸化[1]。 Western Blot Analysis[1] Cell Line: U266 cells Concentration: 0-2 μM Incubation Time: 1 hours Result: Inhibited cytokine induced phosphorylation of JAK1, JAK2, and Tyk2 (P-JAK1-Y1022/1023, P-JAK2-Y1007/1008, P-Tyk2-Y1054/1055). Western Blot Analysis[1] Cell Line: U266 cells Concentration: 0-2 μM Incubation Time: 1 hours Result: Inhibited STAT3 phosphorylation in a dose-dependent manner.

[References]

[1]. Xu J, et, al. Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters. J Med Chem. 2008 Jul 24;51(14):4115-21.  

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
519.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H7F7N2O3

[ Molecular Weight ]:
444.259

[ Flash Point ]:
268.2±30.1 °C

[ Exact Mass ]:
444.034485

[ LogP ]:
1.88

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.566

Related Compounds