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Methoxycarbonyl-D-Nle-Gly-Arg-pNA acetate salt

Names

[ CAS No. ]:
104186-68-7

[ Name ]:
Methoxycarbonyl-D-Nle-Gly-Arg-pNA acetate salt

Biological Activity

[Description]:

Methoxycarbonyl-D-Nle-Gly-Arg-pNA is a synthetic trypsin that can serve as a substrate for coagulation factors IXa (FIXa) and Xa (FXa)[1][2][3].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa

[Target]

Factors IXa[3]


[References]

[1]. Hopfner KP, et al. New enzyme lineages by subdomain shuffling. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9813-8.  

[2]. Hopfner KP, et al. Converting blood coagulation factor IXa into factor Xa: dramatic increase in amidolytic activity identifies important active site determinants. EMBO J. 1997 Nov 17;16(22):6626-35.  

[3]. Sturzebecher J, et al. Dramatic enhancement of the catalytic activity of coagulation factor IXa by alcohols. FEBS Lett. 1997 Jul 28;412(2):295-300.  

Chemical & Physical Properties

[ Molecular Formula ]:
C22H34N8O7

[ Molecular Weight ]:
522.56

Related Compounds