Citenamide

Names

[ Name ]:
Citenamide

[Synonym ]:
Citenamide
Dibenzo<a,e>cycloheptatrien-5-carboxamid
5H-Dibenzo<a.d>cyclohepten-5-carbonsaeureamid
Dibenzo<a,e>1,3,5-cycloheptatrien-5-carboxamid
Cytenamide
AY-15,613
percentH-Dibenzo<a,b>cyclohepten-5-carboxamid

Biological Activity

[Description]:

Citenamide is an anticonvulsant.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vivo]

Citenamide (Cytenamide, CYT) is an analogue of Carbamazepine (CBZ), a dibenzazepine drug used to control seizures.

[References]

[1]. Johnston A, et al. Cytenamide-formic acid (1/1). Acta Crystallogr Sect E Struct Rep Online. 2008 Jul 5;64(Pt 8):o1379-80.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.203g/cm3

[ Boiling Point ]:
487.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₃NO

[ Molecular Weight ]:
235.28100

[ Flash Point ]:
248.4ºC

[ Exact Mass ]:
235.10000

[ PSA ]:
43.09000

[ LogP ]:
3.48790

[ Vapour Pressure ]:
1.23E-09mmHg at 25°C

[ Index of Refraction ]:
1.643

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HO7700000

CHEMICAL NAME :: 5H-Dibenzo(a,d)cycloheptene-5-carboxamide

CAS REGISTRY NUMBER :: 10423-37-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C16-H13-N-O

MOLECULAR WEIGHT :: 235.30

WISWESSER LINE NOTATION :: L C676 BHJ BVZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,65,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 540 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,65,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1550 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,65,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 582 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 7,88,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 440 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,91,1972

Safety Information

[ HS Code ]:
2924299090

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%