GSK-1520489A

Names

[ CAS No. ]:
1042433-41-9

[ Name ]:
GSK-1520489A

Biological Activity

[Description]:

GSK-1520489A is a PKMYT1 (active protein kinase) inhibitor (IC50=115 nM, Ki=10.94 nM)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

IC50: 115 nM (PKMYT1)[1]

[In Vitro]

GSK-1520489A (4 µM, 24 h) treatment shows inhibition of phosphorylation of Tyr15 in Cdk1[1]. Western Blot Analysis[1] Cell Line: HT29 cells Concentration: 4 µM Incubation Time: 24 hours Result: Reduced Cdk1-phosphorylation at tyrosine in comparison to the uninhibited reaction.

[References]

[1]. Charlott Platzer, et al. Identification of PKMYT1 inhibitors by screening the GSK published protein kinase inhibitor set I and II. Bioorg Med Chem. 2018 Aug 7;26(14):4014-4024.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₃N₅O₃S

[ Molecular Weight ]:
425.50

GSK-1520489A

Names

Biological Activity

Chemical & Physical Properties

Related Compounds