Eslicarbazepine

Names

[ Name ]:
Eslicarbazepine

[Synonym ]:
(+)-Licarbazepine
(S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
(S)-(+)-licarbazepine
5H-Dibenz[b,f]azepine-5-carboxamide, 10,11-dihydro-10-hydroxy-, (10S)-
T C676 BN&T&J BVZ IQ &&S Form
MHD
(S)-10-hydroxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
Eslicarbazepine
5-hydroxy-4a,5-dihydro-4H-dibenzo[b,f]azepine-10-carboxamide
(10S)-10-Hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide
S-licarbazepine
(S)-Licarbazepine
S5VXA428R4

Biological Activity

[Description]:

Eslicarbazepine is an oral anticonvulsant indicated for the adjunctive treatment of partial seizures.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vivo]

Eslicarbazepine is an anti-epileptic drug, chemically related to carbamazepine but with a more favorable safety profile. Eslicarbazepine acetate is a prodrug for eslicarbazepine (S-licarbazepine), which is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel[1][2].

[References]

[1]. Finelli E, et al. Patch testing in a case of eslicarbazepine and carbamazepine induced cutaneous reaction. Eur Ann Allergy Clin Immunol. 2018 Sep;50(5):229-231.

[2]. Sibhghatulla Shaikh, et al. Aptiom (Eslicarbazepine Acetate) as a Dual Inhibitor of β-Secretase and Voltage-Gated Sodium Channel: Advancement in Alzheimer's Disease-Epilepsy Linkage via an Enzoinformatics Study. CNS & Neurological Disorders Drug Targets Volume 13 , Issue 7 , 2014.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
431.3±55.0 °C at 760 mmHg

[ Melting Point ]:
188-190°C

[ Molecular Formula ]:
C₁₅H₁₄N₂O₂

[ Molecular Weight ]:
254.284

[ Flash Point ]:
214.6±31.5 °C

[ Exact Mass ]:
254.105530

[ PSA ]:
66.56000

[ LogP ]:
0.93

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.677

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%