2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate

Names

[ Name ]:
2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate

[Synonym ]:
Asobamast
Acetic acid,2-[[4-(3-methyl-5-isoxazolyl)-2-thiazolyl]amino]-2-oxo-,2-ethoxyethyl ester
2-ethoxyethyl{[4-(3-methyl-1,2-oxazol-5-yl)-1,3-thiazol-2-yl]amino}(oxo)acetate
2-ethoxyethyl N-[4-(3-methyl-5-isoxazolyl)-2-thiazolyl]oxamate
Asobamastum [INN-Latin]
UNII-F0R68O7C4V
Asobamastum

Biological Activity

[Description]:

Asobamast is a potent, orally active antiallergic agent that inhibits ige mediated passive pulmonary allergic responses in rats (ED50=4.7 mg/kg) and inhibits antigen-induced mediator release from sensitized guinea pig lung fragments[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. D Chiarino, et al. N-(4-Isoxazolylthiazol-2-yl)oxamic acid derivatives as potent orally active antianaphylactic agents. J Med Chem. 1991 Feb;34(2):600-5.

Chemical & Physical Properties

[ Density]:
1.363g/cm3

[ Molecular Formula ]:
C₁₃H₁₅N₃O₅S

[ Molecular Weight ]:
325.34000

[ Exact Mass ]:
325.07300

[ PSA ]:
131.79000

[ LogP ]:
1.69770

[ Index of Refraction ]:
1.574

Safety Information

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%