Dihydroethidium

Names

[ Name ]:
Dihydroethidium

[Synonym ]:
3,8-Phenanthridinediamine, 5-ethyl-5,6-dihydro-6-phenyl-
3,8-Phenanthridinediamine, 5-ethyl-5,6-dihydro-6-phenyl-, (±)-
dihydroethidium
MFCD00077335
5,6-dihydro-3,8-diamino-5-ethyl-6-phenylphenanthridine
5-Ethyl-6-phenyl-5,6-dihydro-3,8-phenanthridinediamine
Phenanthridine, 5,6-dihydro-3,8-diamino-5-ethyl-6-phenyl-

Biological Activity

[Description]:

Dihydroethidium(Hydroethidine; PD-MY 003) is a superoxide indicator; exhibits blue-fluorescence in the cytosol until oxidized, where it intercalates within the cell's DNA, staining its nucleus a bright fluorescent red.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Dye Reagents

Research Areas >> Others

[References]

[1]. Zielonka J, et al. Global profiling of reactive oxygen and nitrogen species in biological systems: high-throughput real-time analyses. J Biol Chem. 2012 Jan 27;287(5):2984-95.

[2]. Kwong C, et al. Tumor-associated a2 vacuolar ATPase acts as a key mediator of cancer-related inflammation by inducing pro-tumorigenic properties in monocytes. J Immunol. 2011 Feb 1;186(3):1781-9.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
580.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₁N₃

[ Molecular Weight ]:
315.411

[ Flash Point ]:
299.5±24.9 °C

[ Exact Mass ]:
315.173553

[ PSA ]:
55.92000

[ LogP ]:
3.06

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.680

[ Storage condition ]:
−20°C

[ Water Solubility ]:
acetonitrile: soluble

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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